Potassium → 4-Methyl-6-nitro-1H-indole

HRID 1290565Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290565
[K].C(OCC)(=O)C([O-])=O.[CH3:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][C:12]=1[N:21]=[CH:22]OC>CN(C)C=O>[CH3:17][C:16]1[CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=[C:12]2[C:11]=1[CH:10]=[CH:22][NH:21]2

Komponenten

5

Edukt 3

HCID 5462222PotassiumHCID 21218303HCID 21218303, VerbindungHCID 21943339Ethanedioic acid, monoethyl ester

Produkt 1

HCID 212182864-Methyl-6-nitro-1H-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel2×

Reaktionsbedingungen

Temperatur
40 °C

Versuchsvorschrift

A solution of 31 g of potassium ethoxylate, 51 ml of ethyl oxalate and 0.25 l of dimethylformamide is added to a solution of methyl N-(2,3-dimethyl-5-nitrophenyl)formimidate (52 g) in 0.37 l of dimethylformamide. The temperature of the mixture is raised to 40° C. for 3 hours. The precipitate is filtered off and washed with water. The precipitate is taken up in hot isopropyl ether and then filtration is carried out.

Aufarbeitung

  1. filtrationThe precipitate is filtered off
  2. washwashed with water
  3. filtrationfiltration

Quellen und Nachweise

ORD-Eintrag
ord-22a241a7c279457799d51da4b15e6f1e
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05752982

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