[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH2:5][CH2:6][C:7](=[CH:14]OC)[C:8]2=O.S(O)(O)(=O)=O.[CH3:22][S:23][C:24](=[NH:26])[NH2:25].C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH3:1][O:2][C:3]1[C:4]2[CH2:5][CH2:6][C:7]3[CH:14]=[N:25][C:24]([S:23][CH3:22])=[N:26][C:8]=3[C:9]=2[CH:10]=[CH:11][CH:12]=1To a solution of 5-methoxy-2-methoxymethylene-1-tetralone (9.78 g) in tetrahydrofuran (200 ml) was added 2-methyl-2-thiopseudourea sulfate (8.34 g), followed by potassium carbonate (9.7 g), and the mixture was refluxed overnight. Solvent was then removed under reduced pressure, the residue stirred with diethyl ether, and filtered. Concentration of the filtrate gave a brown solid, which upon crystallization from ethanol gave 7-methoxy-2-methylthio-5,6-dihydrobenzo[h]quinazoline (8.3 g) as a light brown solid.
Wird geladen…
