Potassium Hydroxide → HCID 13565856, Verbindung

HRID 1290884Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290884
Cl.[NH2:2][CH:3]1[CH2:9][CH:8]2[NH:10][CH:5]([CH2:6][CH2:7]2)[CH2:4]1.[OH-].[K+]>C(O)C>[NH2:2][CH:3]1[CH2:4][CH:5]2[NH:10][CH:8]([CH2:7][CH2:6]2)[CH2:9]1

Komponenten

4

Edukt 2

HCID 14797Potassium HydroxideHCID 18919578HCID 18919578, Verbindung

Produkt 1

HCID 13565856HCID 13565856, VerbindungAusbeute 35,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel2×

Versuchsvorschrift

After completion of the hydrogenation, insoluble matters were filtered off and 40 ml of conc. hydrochloric acid was added to the filtrate. The solvent was distilled off under vacuum and the residue was recrystallized from ethanol to give 8.3 g of 3-amino-8-azabicyclo[3.2.1]octane hydrochloride. After 8.3 g of the hydrochloride was added to 100 ml of ethanol, a solution of 5.2 g of potassium hydroxide in 50 ml of ethanol was added to the mixture followed by stirring at room temperature for 3 hours. Insoluble matters were filtered off and the solvent was then distilled off to give 2.3 g of 3-amino-8-azabicyclo[3.2.1]octane.

Aufarbeitung

  1. filtrationInsoluble matters were filtered off
  2. distillationthe solvent was then distilled off

Quellen und Nachweise

ORD-Eintrag
ord-f61dbc2b477d4411ac458a90a82b4fd3
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753673

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