4-Nitrophenol → HCID 18919687, Verbindung

HRID 1290886Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290886
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14](Cl)=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2].[CH:18]1[C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=[C:20]([OH:27])[CH:19]=1>C1(C)C=CC=CC=1>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:27][C:20]2[CH:19]=[CH:18][C:23]([N+:24]([O-:26])=[O:25])=[CH:22][CH:21]=2)=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 9804-NitrophenolHCID 154686831-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride

Produkt 1

HCID 18919687HCID 18919687, VerbindungAusbeute 40,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a solution of 1.0 g of l-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride in 30 ml of toluene was added 0.55 g of p-nitrophenol. The mixture was stirred overnight at room temperature. After solvent was distilled off, the residue was extracted with ether. The solvent was again distilled off. The resulting solid was washed with a small quantity of cold ether to give 0.56 g of 4-nitrophenyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate.

Aufarbeitung

  1. distillationAfter solvent was distilled off
  2. extractionthe residue was extracted with ether
  3. distillationThe solvent was again distilled off
  4. washThe resulting solid was washed with a small quantity of cold ether

Quellen und Nachweise

ORD-Eintrag
ord-8b045b012f08440cabf91ada4308176e
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753673

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