Thionyl Chloride → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride

HRID 1290896Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1290896
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14](O)=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2].S(Cl)([Cl:20])=O>C1(C)C=CC=CC=1>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([Cl:20])=[O:15])[C:5]1=[O:17])([CH3:3])[CH3:2]

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

Produkt 1

HCID 154686831-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A solution of 3.88 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid and 5.0 ml of thionyl chloride in 50 ml of toluene was stirred at 100° C. for 5 hours. After toluene was distilled off under vacuum, toluene was again added to the residue. The solvent was again distilled off under vacuum to give 4.22 g of 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarbonyl chloride.

Aufarbeitung

  1. distillationAfter toluene was distilled off under vacuum, toluene
  2. additionwas again added to the residue
  3. distillationThe solvent was again distilled off under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d0f69c7de59b487981d6fbf30e0cf1df
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05753673

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