Ammonia → 4-Methoxyphenylbenzo[d]oxazole-4-carboxamide

HRID 1292138Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1292138
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([O:20]C)=O)[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1.[NH3:22]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[O:10][C:11]3[C:12](=[C:14]([C:18]([NH2:22])=[O:20])[CH:15]=[CH:16][CH:17]=3)[N:13]=2)=[CH:5][CH:4]=1

Komponenten

3

Edukt 2

HCID 222Ammonia2×HCID 14616764Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate

Produkt 1

HCID 183546064-Methoxyphenylbenzo[d]oxazole-4-carboxamide

Versuchsvorschrift

Methyl 2-(4-methoxyphenyl)benzoxazole-4-carboxylate was dissolved in liquid ammonia (30 ml) and sealed in an autoclave. The reaction mixture was left at 55° C., 20 bar for >20 hours. Once the reaction was complete the ammonia was removed and the resulting solid recrystallised from boiling ethyl acetate and petrol.

Aufarbeitung

  1. customsealed in an autoclave
  2. waitThe reaction mixture was left at 55° C.
  3. wait20 bar for >20 hours
  4. customwas removed
  5. customthe resulting solid recrystallised

Quellen und Nachweise

ORD-Eintrag
ord-08a35897cb694c50b8db1cc76a434d43
Quelldatensatz
uspto-grants-1998_05
Patentnummer
US05756510

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