Ammonia → 2-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

HRID 1292861

Reaktionsgleichung

Reaktionsgleichung von HRID 1292861
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1.[NH3:22]>>[Cl:1][C:2]1[N:11]=[C:10]([NH2:22])[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=3[F:21])[CH:8]=2)[N:3]=1

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 588201952,4-Dichloro-6-(2,4-difluoro-phenoxy)-quinazoline

Produkt 1

HCID 589051302-Chloro-6-(2,4-difluoro-phenoxy)-quinazolin-4-ylamine

Versuchsvorschrift

Compound (1F) (21 g, 0.06 mol) was suspended in ammonia (100 mL of 2.0 M solution in MeOH) and the solution formed after 30 min was stirred at room temperature for 18 h. The precipitate was filtered, the concentrated filtrate triturated with EtOAc, and the organic layers were combined to yield 21.5 g of 2-chloro-6-(2,4-difluorophenoxy)-quinazolin-4-ylamine (1G).

Aufarbeitung

  1. customthe solution formed after 30 min
  2. filtrationThe precipitate was filtered
  3. customthe concentrated filtrate triturated with EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-9a55840aab77422bbbf1d8a693a522b8
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07238698B2

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