Methyl 4-(aminomethyl)benzoate hydrochloride → Methyl 4-[({[2-(4-fluorophenoxy)-5-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)methyl]benzoate

HRID 1293199

Reaktionsgleichung

Reaktionsgleichung von HRID 1293199
[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[N:15]=[CH:14][C:13]([C:16]([F:19])([F:18])[F:17])=[CH:12][C:8]=2[C:9](O)=[O:10])=[CH:4][CH:3]=1.Cl.[NH2:23][CH2:24][C:25]1[CH:34]=[CH:33][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:27][CH:26]=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[C:8]([C:9]([NH:23][CH2:24][C:25]3[CH:26]=[CH:27][C:28]([C:29]([O:31][CH3:32])=[O:30])=[CH:33][CH:34]=3)=[O:10])=[CH:12][C:13]([C:16]([F:19])([F:17])[F:18])=[CH:14][N:15]=2)=[CH:20][CH:21]=1

Komponenten

3

Edukt 2

HCID 2729253Methyl 4-(aminomethyl)benzoate hydrochlorideHCID 575723482-(4-Fluorophenoxy)-5-(trifluoromethyl)nicotinic acid

Produkt 1

HCID 69048049Methyl 4-[({[2-(4-fluorophenoxy)-5-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)methyl]benzoate

Versuchsvorschrift

The title compound was prepared according to the procedure described in step 3 of Example 1 from 2-(4-fluorophenoxy)-5-(trifluoromethyl)nicotinic acid (step 3) and methyl 4-(aminomethyl)benzoate hydrochloride: 1H-NMR (CDCl3) δ 8.90 (1H, d, J=2.7 Hz), 8.45 (1H, s), 8.01 (2H, d, J=8.2 Hz), 7.43 (2H, d, J=8.2 Hz), 4.78 (2H, d, J=5.9 Hz), 3.90 (3H, s); MS (ESI) m/z 449 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-543a57dc490b424e9a3f54ad74f61a70
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07238714B2

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