Ethyl difluoroacetate → 1,3-Butanedione, 1-(3-ethoxyphenyl)-4,4-difluoro-
Reaktionsgleichung
[F:1][CH:2]([F:8])[C:3](OCC)=[O:4].[CH3:9][CH2:10][O:11][C:12]1[CH:17]=[C:16]([C:18]([CH3:20])=[O:19])[CH:15]=[CH:14][CH:13]=1>>[CH2:10]([O:11][C:12]1[CH:17]=[C:16]([C:18](=[O:19])[CH2:20][C:3](=[O:4])[CH:2]([F:8])[F:1])[CH:15]=[CH:14][CH:13]=1)[CH3:9]Komponenten
3
Versuchsvorschrift
Prepared from commercially available ethyl difluoroacetate (16.0 g, 129 mmol) and 3-ethoxyacetophenone (example C.19 step 1) (14.5 g, 88 mmol) as described in example C.1 step 1 to give the title compound (23.90 g, 112%) as a light red oil. MS (ISN) 241.0 [(M−H)−].
Quellen und Nachweise
- ORD-Eintrag
- ord-3189b91d60ad45af9a2ea2afcf4dcc3a
- Quelldatensatz
- uspto-grants-2007_07
- Patentnummer
- US07238808B2
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