Diazomethane → (+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

HRID 1294390Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1294390
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([OH:13])=[O:12])=[C:4]([F:14])[CH:3]=1.[N+](=[CH2:17])=[N-]>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:10][CH:9]2[C:11]([O:13][CH3:17])=[O:12])=[C:4]([F:14])[CH:3]=1

Komponenten

4

Edukt 2

HCID 9550DiazomethaneHCID 438103082-(4-Bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid

Produkt 1

HCID 69157593(+)-Methyl 2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of (+)-2-(4-bromo-2-fluorophenyl)cyclopropanecarboxylic acid from step 7 (1 eq) in methylenechloride was added an ethereal solution of diazomethane until reaction is completed by TLC. The resulting mixture was concentrated. The crude ester was used as such in the next step.

Aufarbeitung

  1. customuntil reaction
  2. concentrationThe resulting mixture was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-f37aadaa08774703a1471ec380b5d890
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07238706B2

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