N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide → N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

HRID 1294568Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1294568
[F:1][C:2]1[C:3]([CH:12]([OH:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[F:1][C:2]1[C:3]([C:12](=[O:20])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[CH3:19])=[C:4]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 1

HCID 69489997N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide

Produkt 1

HCID 69489411N-[3-fluoro-2-(2-methyl-benzoyl)-phenyl]-acetamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

205 mg (0.75 mmol) N-[3-fluoro-2-(hydroxyl-o-tolyl-methyl)-phenyl]-acetamide are dissolved in 9 ml chloroform, combined with 652 mg (7.5 mmol) manganese(IV)-oxide and stirred for 3 d at ambient temperature. Then excess manganese(IV)-oxide is filtered off through Celite and the solvent is eliminated in vacuo. The crude product is purified by column chromatography. The carrier material used is silica gel and the eluant used is a mixture of cyclohexane:ethyl acetate (80:20).

Aufarbeitung

  1. filtrationThen excess manganese(IV)-oxide is filtered off through Celite
  2. customThe crude product is purified by column chromatography
  3. additiona mixture of cyclohexane:ethyl acetate (80:20)

Quellen und Nachweise

ORD-Eintrag
ord-0a32ff9d21694fd790aba529c9ff32d8
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241769B2

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