Imidazole → 1-[2-(4-methylphenyl)ethyl]-1H-imidazole

HRID 129461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129461
CS(O[CH2:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH3:14])=[CH:10][CH:9]=1)(=O)=O.[NH:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH3:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][CH2:6][N:15]2[CH:19]=[CH:18][N:17]=[CH:16]2)=[CH:9][CH:10]=1

Komponenten

5

Edukt 3

HCID 795ImidazoleHCID 11430Potassium CarbonateHCID 12942077HCID 12942077, Verbindung

Produkt 1

HCID 110305321-[2-(4-methylphenyl)ethyl]-1H-imidazoleAusbeute 83 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A mixture of 28.9 g of 2-(4-methylphenyl)ethanol methanesulfonate, 18.6 g of 1H-imidazole, 22.7 g of potassium carbonate and 600 ml of tetrahydrofuran was stirred for 18 hours at reflux temperature. After cooling, the reaction mixture was evaporated and the residue was taken up in water and extracted with 4-methyl-2-pentanone. The extract was dried, filtered and evaporated and the residue was destilled (13.3 Pa; 120° C.), yielding 20.1 g (83.0%) of 1-[2-(4-methylphenyl)ethyl]-1H-imidazole (interm. 6).

Aufarbeitung

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. customthe reaction mixture was evaporated
  4. extractionextracted with 4-methyl-2-pentanone
  5. customThe extract was dried
  6. filtrationfiltered
  7. customevaporated
  8. custom(13.3 Pa; 120° C.)

Quellen und Nachweise

ORD-Eintrag
ord-f5becf5be765473c9021c08a83365753
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05468743

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