Hydrochloric Acid → 3-[4-(benzyloxy)phenoxy]quinuclidine Hydrochloride

HRID 1294662

Reaktionsgleichung

Reaktionsgleichung von HRID 1294662
[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][C:12]([O:13][CH:14]2[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:24].O1CCOCC1>C(OCC)(=O)C>[ClH:24].[CH2:1]([O:8][C:9]1[CH:23]=[CH:22][C:12]([O:13][CH:14]2[CH:19]3[CH2:20][CH2:21][N:16]([CH2:17][CH2:18]3)[CH2:15]2)=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 695192803-[4-(Benzyloxy)phenoxy]quinuclidine

Produkt 1

HCID 695210903-[4-(benzyloxy)phenoxy]quinuclidine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

The product of Example 15A (100 mg, 0.32 mmol) in ethyl acetate (5 mL) was treated with 4M HCl in 1,4-dioxane (0.5 mL, 2.0 mmol). The title compound was obtained as a solid (80 mg, yield, 72%). 1H NMR (MeOH-d4, 300 MHz) δ 1.80–2.16 (m, 3H), 2.25–2.40 (m, 1H), 2.46 (m, 1H), 3.30–3.46 (m, 5H), 3.76 (m, 1H), 4.75 (m, 1H), 5.02 (s, 2H), 6.80–6.95 (m, 4H), 7.28–7.40 (m, 5H) ppm. MS (DCl/NH3) m/z 310 (M+H)+. Anal. calculated for C20H23NO2.1.4HCl.0.8H2O: C, 64.08; H, 6.99; N, 3. 74. Found: C, 64.14; H, 6.52; N, 3.86.

Quellen und Nachweise

ORD-Eintrag
ord-85cd0678afe94bc79ba48473761c7b75
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241773B2

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