Hydrochloric Acid → Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

HRID 1294704

Reaktionsgleichung

Reaktionsgleichung von HRID 1294704
[CH3:1][C:2]1[C:7]([CH2:8][C:9]#[N:10])=[CH:6][CH:5]=[CH:4][N:3]=1.[CH2:11]([OH:13])[CH3:12].[ClH:14]>C(Cl)Cl>[ClH:14].[CH3:1][C:2]1[C:7]([CH2:8][C:9](=[NH:10])[O:13][CH2:11][CH3:12])=[CH:6][CH:5]=[CH:4][N:3]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 190992862-(2-Methylpyridin-3-yl)acetonitrile

Produkt 1

HCID 69411260Ethyl 2-(2-methylpyridin-3-yl)ethanimidoate hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Through a stirred solution of Example 20A (1.7 g, 12.86 mmol) in absolute ethanol (0.89 g, 19.35 mmol) and anhydrous methylene chloride (25 ml) was bubbled with hydrogen chloride gas for 20 min. The mixture was allowed to stand overnight in the refrigerator. The product was precipitated with anhydrous ether and filtered to obtain the title compound, which was immediately used in the next step. MS (ESI+) m/z 180 (M+H)+.

Aufarbeitung

  1. customThe product was precipitated with anhydrous ether
  2. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-f5ea94eab2534c5faee47406155d52cb
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07241776B2

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