Reaktionsgleichung
[Na+:1].[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:18]([CH3:20])[CH3:19])[C:10]=2[CH2:21][CH2:22][CH:23]([OH:31])[CH2:24][C:25]([OH:30])=[CH:26][C:27]([O-:29])=[O:28])=[CH:5][CH:4]=1>C(O)C>[CH3:20][CH:18]([N:11]1[C:10](/[CH:21]=[CH:22]/[C@@H:23]([OH:31])[CH2:24][C@@H:25]([OH:30])[CH2:26][C:27]([O-:29])=[O:28])=[C:9]([C:6]2[CH:7]=[CH:8][C:3]([F:2])=[CH:4][CH:5]=2)[C:17]2[C:12]1=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH3:19].[Na+:1]Komponenten
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
2 g of fluvastatin sodium (prepared according to Example 8 of U.S. Pat. No. 4,739,073 and Example 14D of U.S. Pat. No. 5,354,772 A) heated to boiling in 35 ml of ethanol until the material goes into solution. The hot solution obtained is filtered into 80 ml of boiling 2-propanol and allowed to cool to room temperature, while the precipitation of the anhydrous amorphous form of fluvastatin sodium salt begins. The suspension obtained is allowed to stand at 40° C. for 4 hours, and then filtered, washed with cold ethanol (4° C.) and dried in vacuum at room temperature. Thus 1.4 g of anhydrous amorphous fluvastatin sodium salt is obtained (yield 70%). X-ray powder diffraction examination (FIG. 3 as shown in the accompanied drawings) confirmed the amorphous nature of the product.
Aufarbeitung
- temperature5,354,772 A) heated
- customThe hot solution obtained
- filtrationis filtered into 80 ml of boiling 2-propanol
- customThe suspension obtained
- filtrationfiltered
- washwashed with cold ethanol (4° C.)
- customdried in vacuum at room temperature
Quellen und Nachweise
- ORD-Eintrag
- ord-a5c529b99bde4fbfb42b39db495e927a
- Quelldatensatz
- uspto-grants-2007_07
- Patentnummer
- US07241800B2
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