Thionyl Chloride → HCID 86602055, Verbindung
Reaktionsgleichung
[CH2:1]([N:8]1[CH2:13][CH:12]2[C@@:10]([C:14](O)=[O:15])([CH2:11]2)[C@@H:9]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:25])=O>>[CH2:1]([N:8]1[CH2:13][CH:12]2[C@@:10]([C:14]([Cl:25])=[O:15])([CH2:11]2)[C@@H:9]1[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
To racemic Intermediate 39, one enantiomer being (1S,2S)-3-benzyl-2-phenyl-3-aza-bicyclo[3.1.0]hexane-1-carboxylic acid (0.16 g, 0.56 mmol) was added thionyl chloride (2 mL) dropwise with stirring. The homogeneous solution was refluxed gently for 2 hours. The solvent was removed at reduced pressure to yield the title compound (0.17 g, quantitative yield) as an oil, which was used without further purification.
Aufarbeitung
- temperatureThe homogeneous solution was refluxed gently for 2 hours
- customThe solvent was removed at reduced pressure