Methanol → HCID 10931849, Verbindung

Reaktionsgleichung

[CH3:1][C:2]([C:6]([OH:8])=[O:7])([CH2:4][OH:5])[NH2:3].O=S(Cl)Cl.[CH3:13]O>>[CH3:13][O:7][C:6](=[O:8])[C:2]([NH2:3])([CH3:1])[CH2:4][OH:5]

Komponenten

Edukt 3

HCID 887Methanol

HCID 24386Thionyl Chloride2×

HCID 943092-Methylserine

Produkt 1

HCID 10931849HCID 10931849, Verbindung

Reaktionsbedingungen

Temperatur: 0 °C

Versuchsvorschrift

A strring solution of α-methyl-DL-Serine (1 g, 8.39 mmol) in MeOH (40 mL) in a flame dried round bottom flask under an inert atmosphere was cooled to 0° C. and SOCl2 (1.84 mL, 25.19 mmol) was slowly added. After addition of the SOCl2 was complete, the reaction mixture was stirred 12 h at rt and then concentrated in vacuo to a white solid that was used directly in the next reaction.