Ammonia → 114812-34-9

HRID 129574Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 129574
[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([O:10]CC)=O)[CH3:2].[NH3:13]>CO>[CH2:1]([N:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([NH2:13])=[O:10])[CH3:2]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 10942897Ethyl (S)-(-)-1-Ethyl-2-pyrrolidinecarboxylate

Produkt 1

HCID 10866443114812-34-9

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Ethyl (-)-(S)-1-ethyl-2-pyrrolidinecarboxylate (3.4 g, 0.02 mol) was added to a cooled solution of MeOH (10 ml) and liquid NH3 (10 ml) in a stainless steel reaction bottle containing 3 g of 3 A molecular sieves. The bottle was heated at 50° C. for 20 h. After cooling the solvent was allowed to evaporate. The product was dissolved in dry MeOH, filtered and the filtrate was evaporated under reduced pressure to give the title compound as white crystals in a quantitative yield (2.8 g).

Aufarbeitung

  1. temperatureAfter cooling the solvent
  2. customto evaporate
  3. dissolutionThe product was dissolved in dry MeOH
  4. filtrationfiltered
  5. customthe filtrate was evaporated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-7c33fdd0a3dd4474ac38d60444b2d4a3
Quelldatensatz
uspto-grants-1995_11
Patentnummer
US05468876

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