(4-Butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone → (4-Butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	(4-Butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone	HCID 69240993	—
Katalysator	Hexylamine	HCID 8102	—
Lösungsmittel	Acetonitrile--water (1/1)	HCID 18373917	—
Produkt	(4-Butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone	HCID 69240836	101,8%

Reaktionsschritte

In a sealed glass tube, (4-butyl-phenyl)-[4-(2-methanesulfonyl-benzoimidazol-1-yl)-piperidin-1-yl]-methanone (9 mg) and hexyl amine (3 drops) were heated at 120-150° C. for 18 h. The crude product was taken into 1 ml 1:1 acetonitrile/water and purified via preparative liquid chromatography to give (4-butyl-phenyl)-[4-(2-hexylamino-benzoimidazol-1-yl)-piperidin-1-yl]-methanone (4.8 mg).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07244744B2
Quelldatensatz	uspto-grants-2007_07
ORD ID	ord-44a2ef12a0f64059957e2f9213b5a80a
Quellennotiz	uspto-grants-2007_07