HCID 58910028, Verbindung → HCID 22929848, Verbindung

HRID 1295926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1295926
[Br:1][CH2:2][C:3]1[C:19]([C:20]#[N:21])=[CH:18][C:6]([C:7]([N:9](C)[C:10](=O)OC(C)(C)C)=[O:8])=[C:5]([O:22][CH2:23][CH3:24])[CH:4]=1>ClCCl.FC(F)(F)C(O)=O>[CH3:10][NH:9][C:7](=[O:8])[C:6]1[CH:18]=[C:19]([C:20]#[N:21])[C:3]([CH2:2][Br:1])=[CH:4][C:5]=1[O:22][CH2:23][CH3:24]

Komponenten

4

Edukt 1

HCID 58910028HCID 58910028, Verbindung

Produkt 1

HCID 22929848HCID 22929848, VerbindungAusbeute 66,2 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6344DichloromethaneLösungsmittelHCID 6422Trifluoroacetic acidLösungsmittel

Versuchsvorschrift

After dissolving tert-butyl N-[4-(bromomethyl)-5-cyano-2-ethoxybenzoyl]-N-methylcarbamate (39.9 g) in dichloromethane (300 ml), trifluoroacetic acid (50 ml) was added and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated and the residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate) to yield the title compound (19.77 g) as a white solid.

Aufarbeitung

  1. additionwas added
  2. concentrationThe reaction mixture was concentrated
  3. customthe residue was purified by silica gel column chromatography (solvent: n-hexane-ethyl acetate)

Quellen und Nachweise

ORD-Eintrag
ord-7a61708904724355b3082024bbb79ca3
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244730B2

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