Sodium Azide → HCID 22929860, Verbindung

HRID 1295931Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1295931
[CH3:1][NH:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]#[N:11])[C:7]([CH2:12]Br)=[CH:6][C:5]=1[O:14][CH2:15][CH3:16].[N-:18]=[N+:19]=[N-:20].[Na+]>CN(C)C=O.C(OCC)(=O)C>[CH3:1][NH:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]#[N:11])[C:7]([CH2:12][N:18]=[N+:19]=[N-:20])=[CH:6][C:5]=1[O:14][CH2:15][CH3:16]

Komponenten

5

Edukt 2

HCID 33557Sodium AzideHCID 22929848HCID 22929848, Verbindung

Produkt 1

HCID 22929860HCID 22929860, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideLösungsmittelHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

After next dissolving N1-methyl-4-(bromomethyl)-5-cyano-2-ethoxybenzamide in dimethylformamide (100 ml), sodium azide (6 g) was added and the mixture was stirred at room temperature overnight. The reaction mixture was diluted with ethyl acetate and washed with water and brine, and then the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to yield the title compound (15.5 g).

Aufarbeitung

  1. additionwas added
  2. washwashed with water and brine
  3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-43853107778648858acce18d15230245
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07244730B2

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