Piperazine → HCID 18186929, Verbindung

HRID 1296673Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1296673
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][C:10]2[CH:14]=[C:13]([C:15]3[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=3)[O:12][C:11]=2[CH3:22])[N:3]=1.ClC1C=CC(C2OC(C)=C(CO)C=2)=CC=1.[NH:38]1[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]1.C([O-])([O-])=O.[K+].[K+]>>[Cl:21][C:18]1[CH:19]=[CH:20][C:15]([C:13]2[O:12][C:11]([CH3:22])=[C:10]([CH2:9][O:8][C:4]3[CH:5]=[N:6][CH:7]=[C:2]([N:38]4[CH2:43][CH2:42][NH:41][CH2:40][CH2:39]4)[N:3]=3)[CH:14]=2)=[CH:16][CH:17]=1

Komponenten

5

Edukt 4

HCID 4837PiperazineHCID 11430Potassium CarbonateHCID 7245332[5-(4-Chlorophenyl)-2-methylfuran-3-yl]methanolHCID 18186841HCID 18186841, Verbindung

Produkt 1

HCID 18186929HCID 18186929, Verbindung

Versuchsvorschrift

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-[5-(4-chlorophenyl)-2-methylfuran-3-ylmethoxy]pyrazine [3.14 g, 9.39 mmol; obtained according to the procedure of example 50, step 1, starting from 5-(4-chlorophenyl)-3-hydroxymethyl-2-methylfuran], piperazine (2.47 g, 28.6 mmol) and K2CO3 (1.36 g, 9.86 mmol) with the exception that the final filtration through alumina was omitted. The yield of the of the title compound was 2.11 g (58%) which was obtained as a beige colored solid. Purity 100% (HPLC). MS m/z 384 (M)+. HRMS m/z calcd for C20H21ClN4O2 (M)+ 384.1353, found 384.1357.

Aufarbeitung

  1. customobtained
  2. filtrationfiltration through alumina
  3. customwas obtained as a beige colored solid

Quellen und Nachweise

ORD-Eintrag
ord-c297c2f9bb2a4770a7e22b6c4fcefca5
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07247633B2

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