Sodium Bicarbonate → HCID 11416722, Verbindung

HRID 1296955Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1296955
C[O:2][C:3]([C:5]1[O:6][C:7]2[C:12]([C:13](=[O:23])[C:14]=1[C:15]1[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=1)=[CH:11][C:10]([Cl:24])=[C:9]([OH:25])[CH:8]=2)=[O:4].C([O-])(O)=O.[Na+]>CO>[Cl:24][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][C:9]=1[OH:25])[O:6][C:5]([C:3]([OH:4])=[O:2])=[C:14]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH3:22])=[CH:19][CH:20]=1)[C:13]2=[O:23]

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 11233736HCID 11233736, Verbindung

Produkt 1

HCID 11416722HCID 11416722, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

6-Chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid methyl ester was taken up in a 2:1 mixture of sat. NaHCO3 (aq): Methanol and all was heated at 65° C. for 5 hours. The solution was cooled to room temperature and concentrated in vacuo to remove the methanol. The residual aqueous solution was acidified with 1M HCl (aq) and a buff coloured precipitated dropped out of solution. This was collected by vacuum filtration, washed with water and with diethyl ether, to give 6-chloro-7-hydroxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromene-2-carboxylic acid.

Aufarbeitung

  1. concentrationconcentrated in vacuo
  2. customto remove the methanol
  3. customa buff coloured precipitated
  4. additiondropped out of solution
  5. filtrationThis was collected by vacuum filtration
  6. washwashed with water and with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-bb47942497dc468684708e317f892498
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07247734B2

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