Chloroacetone → HCID 11448585, Verbindung

HRID 1297062Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1297062
[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[NH:8][S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1.[H-].[Na+].Cl[CH2:18][C:19](=[O:21])[CH3:20]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:14]=[CH:13][C:6]2[C:7](=[O:12])[N:8]([CH2:18][C:19](=[O:21])[CH3:20])[S:9](=[O:11])(=[O:10])[C:5]=2[CH:4]=1

Komponenten

5

Edukt 3

HCID 6571ChloroacetoneHCID 24758Sodium hydrideHCID 110747271,2-BENZISOTHIAZOL-3(2H)-ONE, 6-METHOXY, 1,1-DIOXIDE

Produkt 1

HCID 11448585HCID 11448585, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

360 mg of 6-methoxy-1,1-dioxo-1,2-dihydro-benzo[d]isothiazol-3-one are added in small portions to a suspension of 72 mg of 60% NaH in mineral oil in 1.6 ml of anhydrous dimethylformamide. After stirring for 30 min. at ambient temperature, the reaction mixture becomes homogeneous and 162 μl of chloroacetone are added thereto. The reaction mixture is heated at 110° C. for 30 min. It is allowed to return to ambient temperature, and then the mixture is precipitated by addition of water. The precipitate is filtered off, rinsed several times with water, suction-filtered off and dried in vacuo.

Aufarbeitung

  1. temperatureThe reaction mixture is heated at 110° C. for 30 min
  2. customto return to ambient temperature
  3. customthe mixture is precipitated by addition of water
  4. filtrationThe precipitate is filtered off
  5. washrinsed several times with water
  6. filtrationsuction-filtered off
  7. customdried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-c0cd1929272e495ab5a28251665a08e4
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07250411B2

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