2-Bromothiazole → 5-(2,6-dimethoxypyridin-3-yl)-N-[(3R,4S)-4-ethoxy-1-(1,3-thiazol-2-yl)pyrrolidin-3-yl]-3,6-diethylpyrazin-2-amine

Reaktionsgleichung

C(O[C@H]1CN(C2N=CC=CN=2)C[C@H]1NC1C(CC)=NC(C2C(C)=NC(OC)=CC=2)=C(CC)N=1)C.Br[C:36]1[S:37][CH:38]=[CH:39][N:40]=1.[CH3:41][O:42][C:43]1[C:48]([C:49]2[N:50]=[C:51]([CH2:66][CH3:67])[C:52]([NH:57][C@H:58]3[C@@H:62]([O:63][CH2:64][CH3:65])[CH2:61][NH:60][CH2:59]3)=[N:53][C:54]=2[CH2:55][CH3:56])=[CH:47][CH:46]=[C:45]([O:68][CH3:69])[N:44]=1>>[CH3:41][O:42][C:43]1[C:48]([C:49]2[N:50]=[C:51]([CH2:66][CH3:67])[C:52]([NH:57][C@H:58]3[C@@H:62]([O:63][CH2:64][CH3:65])[CH2:61][N:60]([C:36]4[S:37][CH:38]=[CH:39][N:40]=4)[CH2:59]3)=[N:53][C:54]=2[CH2:55][CH3:56])=[CH:47][CH:46]=[C:45]([O:68][CH3:69])[N:44]=1