Hexahydro-1,4-diazepine → 1-{2-[Bis-(4-fluoro-phenyl)-methoxy]-ethyl}-[1,4]diazepane
Reaktionsgleichung
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11]Cl)=[CH:4][CH:3]=1.[NH:20]1[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=2)[O:9][CH2:10][CH2:11][N:20]2[CH2:26][CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[CH:4][CH:3]=1Komponenten
3
Versuchsvorschrift
Following a procedure similar to that described in Preparation 1, but using 2-[bis(4-fluorophenyl)methoxy]ethyl chloride and homopiperazine, the title compound was obtained in a yield of 88%.
Aufarbeitung
- customthat described in Preparation 1
Quellen und Nachweise
- ORD-Eintrag