Ethyl indole-2-carboxylate → 5-fluoro-1-methyl-1H-indole-3-carbaldehyde

HRID 1297392

Reaktionsgleichung

Reaktionsgleichung von HRID 1297392
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]=[O:12].N1C2C(=CC=CC=2)C=[C:14]1C(OCC)=O>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:14])[CH:6]=[C:5]2[CH:11]=[O:12]

Komponenten

3

Edukt 2

HCID 73125Ethyl indole-2-carboxylateHCID 2590895-fluoro-1H-indole-3-carbaldehyde

Produkt 1

HCID 13820095-fluoro-1-methyl-1H-indole-3-carbaldehydeAusbeute 50 %

Versuchsvorschrift

According to the procedure of Preparation 9 (a), except substituting 5-fluoro-1H-indole-3-carboxaldehyde (0.3 g, 1.8 mmole) for the ethyl indole-2-carboxylate, the title compound (0.16 g, 50%) was prepared as a viscous oil: MS (ES) m/e 178 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-00460c95be714cef8aaa04b42bf839c6
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07250424B2

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