1,3-dimethyl-1H-indole-2-carbaldehyde → 4-fluoro-1-methyl-3-(methylaminomethyl)-1H-indole

HRID 1297395

Reaktionsgleichung

Reaktionsgleichung von HRID 1297395
BrC1C=C[C:5](NCC(OC)=O)=[N:6]C=1.[F:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH:25]=O)=[CH:18][N:19]2[CH3:24].CN1C2C(=CC=CC=2)C(C)=C1C=O>>[F:14][C:15]1[CH:23]=[CH:22][CH:21]=[C:20]2[C:16]=1[C:17]([CH2:25][NH:6][CH3:5])=[CH:18][N:19]2[CH3:24]

Komponenten

4

Edukt 3

HCID 27714681,3-dimethyl-1H-indole-2-carbaldehydeHCID 221389944-fluoro-1-methyl-1H-indole-3-carbaldehydeHCID 22139049Methyl 2-((5-bromopyridin-2-yl)amino)acetate

Produkt 1

HCID 221391514-fluoro-1-methyl-3-(methylaminomethyl)-1H-indoleAusbeute 77 %

Versuchsvorschrift

According to the procedure of Preparation 11 (c), except substituting 4-fluoro-1-methyl-1H-indole-3-carboxaldehyde (0.3 g, 1.69 mmole) for the 1,3-dimethyl-1H-indole-2-carboxaldehyde, the title compound (0.2 g, 77%) was prepared as a viscous oil: MS (ES) m/e 193 (M+H)+.

Quellen und Nachweise

ORD-Eintrag
ord-0f6f07f5d4d6443280572cfe75e41a60
Quelldatensatz
uspto-grants-2007_07
Patentnummer
US07250424B2

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