Diisopropylamine → 2-Cyanoethyl N,N-diisopropylchlorophosphoramidite

Beteiligte Stoffe

Reaktionsschritte

To a solution of 1.9 mL(13.8 mmol) of dichloro(β-cyano)ethoxyphosphine in 40 mL of dichloromethane cooled in an ice-water bath was added 10 mL of diisopropylethylamine, followed by adding 2.3 mL (13.8 mmol) of diisopropylamine under Argon. The reaction mixture was warmed up to room temperature and stirred for 2 h. After adding 0.1 gm of DMAP into the solution, the reaction mixture is ready for next step reaction.

Herkunft & Nachweise