Triethylamine → N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-2-(6-trifluoromethylquinazolin-4-ylamino)acetamide

HRID 130382Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 130382
[NH2:1][CH2:2][C:3]([NH:5][CH:6]1[CH2:16][CH:9]2[CH2:10][N:11]([CH:13]([CH3:15])[CH3:14])[CH2:12][CH:8]2[CH:7]1[CH2:17][O:18][CH3:19])=[O:4].Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[C:28]([C:31]([F:34])([F:33])[F:32])[CH:29]=2)[N:24]=[CH:23][N:22]=1.C(N(CC)CC)C>C(O)C>[CH:13]([N:11]1[CH2:12][CH:8]2[CH:7]([CH2:17][O:18][CH3:19])[CH:6]([NH:5][C:3](=[O:4])[CH2:2][NH:1][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[C:28]([C:31]([F:33])([F:34])[F:32])[CH:29]=4)[N:24]=[CH:23][N:22]=3)[CH2:16][CH:9]2[CH2:10]1)([CH3:14])[CH3:15]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 210750954-Chloro-6-(trifluoromethyl)quinazolineHCID 692215432-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide

Produkt 1

HCID 69224927N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)-2-(6-trifluoromethylquinazolin-4-ylamino)acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-amino-N-(2-isopropyl-4-methoxymethyloctahydrocyclopenta[c]pyrrol-5-yl)acetamide, 4-chloro-6-trifluoromethylquinazoline (see Armarego et al., J. Chem. Soc. B, 1967, 449) and triethylamine in ethanol is heated at reflux until the reaction is complete. The solution is concentrated under vacuum yielding a residue. The residue is purified by reverse phase HPLC and lyophilization providing the title product.

Aufarbeitung

  1. temperatureis heated
  2. temperatureat reflux until the reaction
  3. concentrationThe solution is concentrated under vacuum
  4. customyielding a residue
  5. customThe residue is purified by reverse phase HPLC and lyophilization

Quellen und Nachweise

ORD-Eintrag
ord-9e161f22675b48dda1bbf83ba3010999
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381738B2

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