Thionyl Chloride → 6-(3-Thienyl)-2-pyridinesulfonyl chloride

HRID 130405Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 130405
[Na+].[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([O-:16])(=O)=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1.S(Cl)([Cl:19])=O>CN(C)C=O>[S:2]1[CH:6]=[CH:5][C:4]([C:7]2[N:12]=[C:11]([S:13]([Cl:19])(=[O:16])=[O:14])[CH:10]=[CH:9][CH:8]=2)=[CH:3]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 59007067HCID 59007067, Verbindung

Produkt 1

HCID 590070916-(3-Thienyl)-2-pyridinesulfonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideKatalysator

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

A mixture of 6-(3-thienyl)-2-pyridinesulfonic acid sodium salt (D9) and N,N-dimethylformamide (1 drop) in thionyl chloride (2 ml) was heated at 70° C. for 2 hours. After cooling to room temperature the solution was concentrated in vacuo and the residue co-evaporated with toluene (×2). The residue was triturated with diethyl ether to afford the title product (D10).

Aufarbeitung

  1. temperatureAfter cooling to room temperature the solution
  2. concentrationwas concentrated in vacuo
  3. customThe residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-6e4c2f59a9c2482a8e1cde73eb428536
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381728B2

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