Hydrogen Peroxide → 6-(4-Formylphenoxy)pyridine-3-carboxamide

HRID 131045Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 131045
[CH:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]#[N:13])=[CH:10][N:9]=2)=[CH:5][CH:4]=1)=[O:2].C([O-])([O-])=[O:19].[K+].[K+].OO>CS(C)=O>[CH:1]([C:3]1[CH:17]=[CH:16][C:6]([O:7][C:8]2[CH:15]=[CH:14][C:11]([C:12]([NH2:13])=[O:19])=[CH:10][N:9]=2)=[CH:5][CH:4]=1)=[O:2]

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 471502166-(4-Formylphenoxy)nicotinonitrile

Produkt 1

HCID 568514226-(4-Formylphenoxy)pyridine-3-carboxamideAusbeute 171,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Combine 6-(4-Formyl-phenoxy)-nicotinonitrile (3.02 g, 13.5 mmol), powdered K2CO3 (0.93 g, 6.7 mmol), and DMSO (100 mL) in a RB flask and add H2O2, 30% wt. Aq (4.05 mL, 13.5 mmol) by dropwise addition at 0° C. Stir the reaction mixture for 3 hours allowing it to come to room temperature then quench the reaction slowly at 0° C. with water. Extract the product out of the water layer with ethyl acetate several times and then wash with brine. Dry over Na2SO4 and concentrate under reduced pressure to give 2.78 g (95% yield) of the title compound: 1H NMR (500 MHz, DMSO); 7.2 (1H, d), 7.3-7.4 (2H, m), 7.5 (1H, br s), 7.9-8.0 (2H, m), 8.1 (1H, br s), 8.3 (1H, d), 8.7 (1H, s), 10.0 (1H, s); MS m/z 243 (M+1).

Aufarbeitung

  1. additionby dropwise addition at 0° C
  2. customto come to room temperature
  3. customthen quench
  4. customthe reaction slowly at 0° C. with water
  5. extractionExtract the product out of the water layer with ethyl acetate several times
  6. washwash with brine
  7. dry with materialDry over Na2SO4
  8. concentrationconcentrate under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-17ca114b68ef4829bfe082eacac8e519
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07381719B2

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