Diisopropylcarbodiimide → 2-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-trifluoromethyl-phenyl)-ethyl]-amide

HRID 131212

Reaktionsgleichung

Reaktionsgleichung von HRID 131212
[O:1]([CH2:8][C:9]1[N:13]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=2)[C:12]2[CH:26]=[CH:27][C:28]([C:30]([OH:32])=O)=[CH:29][C:11]=2[N:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CC(C)N=C=NC(C)C.[F:42][C:43]([F:54])([F:53])[C:44]1[CH:45]=[C:46]([CH:50]=[CH:51][CH:52]=1)[CH2:47][CH2:48][NH2:49]>C1COCC1>[F:42][C:43]([F:53])([F:54])[C:44]1[CH:45]=[C:46]([CH2:47][CH2:48][NH:49][C:30]([C:28]2[CH:27]=[CH:26][C:12]3[N:13]([CH2:14][C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:24])([F:25])[F:23])=[CH:17][CH:16]=4)[C:9]([CH2:8][O:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[N:10][C:11]=3[CH:29]=2)=[O:32])[CH:50]=[CH:51][CH:52]=1

Komponenten

5

Edukt 3

HCID 12734DiisopropylcarbodiimideHCID 104223Phenethylamine, m-trifluoromethyl-HCID 684638462-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid

Produkt 1

HCID 866233592-Phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid [2-(3-trifluoromethyl-phenyl)-ethyl]-amide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.16 mmol of 2-phenoxymethyl-1-(4-trifluoromethoxy-benzyl)-1H-benzoimidazole-5-carboxylic acid were dissolved in 1 ml THF with 1 eq. DIC. After 15 min 1.5 eq of 3-trifluoromethylphenethylamine were added and the reaction stirred at room temperature for 16 h. The crude material was purified via reversed phase preparative HPLC MS(ISP): 614.6 (M+H)+.

Aufarbeitung

  1. customThe crude material was purified via reversed phase preparative HPLC MS(ISP)

Quellen und Nachweise

ORD-Eintrag
ord-36cd648233fe4d2490225dbc8211fb76
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384945B2

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