HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 131247Erstellt: 25. Oktober 2026
Triethylamine → 2-Phenoxymethyl-1H-indole-5-carboxylic acid methyl ester
https://huagongshe.com/reaction/131247
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | (Prop-2-ynyloxy)benzene | HCID 83613 | — |
| Edukt | Methyl 4-amino-3-iodobenzoate | HCID 4104649 | — |
| Katalysator | HCID 178418476 | HCID 178418476 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 2-Phenoxymethyl-1H-indole-5-carboxylic acid methyl ester | HCID 59732213 | — |
Reaktionsschritte
Resin bound 4-amino-3-iodo-benzoic acid methyl ester was suspended in DMF and treated with 15.6 g of phenyl propargylether, 60 ml of triethylamine and catalytic amounts of Cul and bis(triphenylphosphine)palladium(II) chloride. The resin was shaken for 6 h at 50° C. and washed subsequently with DMF, isopropanol/water and diethylether.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patentnummer | US07384945B2 |
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| Quelldatensatz | uspto-grants-2008_06 |
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| ORD ID | ord-9e1a959e9e6c4903be1e469a1db4be79 |
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| Quellennotiz | uspto-grants-2008_06 |
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