Acetoin → 2-Amino-4,5-dimethyl-3-furancarbonitrile

HRID 131288

Reaktionsgleichung

Reaktionsgleichung von HRID 131288
[C:1](#[N:5])[CH2:2][C:3]#[N:4].[OH:6][CH:7]([CH3:11])[C:8](=O)[CH3:9].C(NCC)C>CO>[NH2:4][C:3]1[O:6][C:7]([CH3:11])=[C:8]([CH3:9])[C:2]=1[C:1]#[N:5]

Komponenten

5

Edukt 3

HCID 179AcetoinHCID 8010MalononitrileHCID 8021Diethylamine

Produkt 1

HCID 2902202-Amino-4,5-dimethyl-3-furancarbonitrileAusbeute 75 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel2×

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

To a solution of malononitrile (28.2 g) in methanol (30 mL) is added a suspension of acetoin (25 g) in methanol (30 mL) and thereto is added dropwise diethylamine (11 mL) under ice-cooling (internal temp.: 10° C.). The mixture is stirred at room temperature for 3 hours. The reaction mixture is poured into ice water (300 mL) and the precipitated crystals are collected by filtration to give 2-amino-4,5-dimethyl-3-furonitrile (28.91 g, yield; 75%) as colorless crystals.

Aufarbeitung

  1. filtrationthe precipitated crystals are collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-e457f56050504f0fa27764bfa1e56fd1
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384952B2

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