Methanol → Methyl 4-sulfanylbenzoate

HRID 131298

Reaktionsgleichung

Reaktionsgleichung von HRID 131298
[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][CH:3]=1.S(=O)(=O)(O)O.[CH3:16]O>>[SH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:16])=[O:7])=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 957384-Mercaptobenzoic acid

Produkt 1

HCID 237573Methyl 4-sulfanylbenzoateAusbeute 99 %

Versuchsvorschrift

To a solution of 4-mercaptobenzoic acid (1.5 g) in methanol (20 mL) is added conc. sulfuric acid (0.5 mL) and the mixture is refluxed under heating overnight. The reaction mixture is evaporated to remove solvent and the residue is neutralized with a saturated sodium hydrogencarbonate solution. The mixture is extracted with ethyl acetate and the extract is concentrated in vacuo to give methyl 4-mercaptobenzoate (1.6 g, yield; 99%) as a colorless oil. MS (APCI) m/z: 167 [M−H]−

Aufarbeitung

  1. temperaturethe mixture is refluxed
  2. temperatureunder heating overnight
  3. customThe reaction mixture is evaporated
  4. customto remove solvent
  5. extractionThe mixture is extracted with ethyl acetate
  6. concentrationthe extract is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f51b70acb2e7448bbb18b4a5d91736aa
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384952B2

Verknüpfte Notizen

Wird geladen…