(S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride → (S)-6,7-Difluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

HRID 131475

Reaktionsgleichung

Reaktionsgleichung von HRID 131475
[ClH:1].Cl.[F:3][C:4]1[CH:5]=[CH:6][C:7]2[N:16]=[C:15]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[C@@H:19]([CH2:24][CH2:25][O:26][CH3:27])[CH2:18]3)[C:14]3[CH:13]=[C:12]([CH2:28]C)[S:11][C:10]=3[NH:9][C:8]=2[CH:30]=1.Cl.[F:32]C1C(F)=CC2N=C(N)C3C=C(C)SC=3NC=2C=1>>[ClH:1].[ClH:1].[F:3][C:4]1[C:5]([F:32])=[CH:6][C:7]2[N:16]=[C:15]([N:17]3[CH2:22][CH2:21][N:20]([CH3:23])[C@@H:19]([CH2:24][CH2:25][O:26][CH3:27])[CH2:18]3)[C:14]3[CH:13]=[C:12]([CH3:28])[S:11][C:10]=3[NH:9][C:8]=2[CH:30]=1

Komponenten

3

Edukt 2

HCID 69211696(S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochlorideHCID 1363885776,7-Difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride

Produkt 1

HCID 136384257(S)-6,7-Difluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride

Versuchsvorschrift

Using a method similar to the example (S)-6-fluoro 10-[3-(2-methoxy-ethyl)-4-methyl-piperazin-1-yl]-2-ethyl-4H-3-thia-4,9-diaza-benzo[f]azulene dihydrochloride, using 6,7-difluoro-2-methyl-4H-3-thia-4,9-diaza-benzo[f]azulen-10-ylamine hydrochloride and (S)-2-(2-methoxy)ethylpiperazine: 1H NMR (DMSO-d6): δ 11.7110 (2H, bs), 9.3793 (1H, bs), 7.3795 (1H, bs), 7.0701 (1H, bt), 6.6326 (1H, bs), 4.1000 (3H, bm), 3.6041 (3H, bs), 3.4347 (3H, bs), 3.2081 (3H, bs), 2.8371 (3H, bs), 2.3319 (3H, bs), 2.2842 (1H, bm), 1.8410 (1H, bs); Mass Spectrum M+H=407.1.

Quellen und Nachweise

ORD-Eintrag
ord-ece814ab905142ab83618c5e12eb4934
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384934B2

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