P-Anisidine → N-(4-methoxyphenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide

HRID 131661

Reaktionsgleichung

Reaktionsgleichung von HRID 131661
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([OH:22])=O)=[CH:16][CH:15]=1.[CH3:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([NH2:29])=[CH:27][CH:26]=1>>[CH3:23][O:24][C:25]1[CH:31]=[CH:30][C:28]([NH:29][C:20]([C:17]2[CH:16]=[CH:15][C:14]([C:3]3[CH:4]=[C:5]([C:8]4[O:9][C:10]([CH3:13])=[N:11][N:12]=4)[CH:6]=[CH:7][C:2]=3[CH3:1])=[CH:19][CH:18]=2)=[O:22])=[CH:27][CH:26]=1

Komponenten

3

Edukt 2

HCID 7732P-AnisidineHCID 112201194-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzoic Acid

Produkt 1

HCID 10135552N-(4-methoxyphenyl)-4-[2-methyl-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl]benzamide

Versuchsvorschrift

N-(4-Methoxyphenyl)-2′-methyl-5′-(5methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 4-methoxyaniline using method I. NMR; δH [2H6]—DMSO 10.21,(1H, b), 8.05,(2H, d), 7.90,(1H, dd), 7.79,(1H, d), 7.70,(2H, d), 7.58-7.55,(3H, m), 6.93,(2H, d), 3.74,(3H, s), 2.57,(3H, s), 2.33,(3H, s). LCMS; retention time 3.40 min, MH+ 400.

Quellen und Nachweise

ORD-Eintrag
ord-dd85b2ce43854f96ba880d22d826e054
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07384963B2

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