(4-Phenoxyphenyl)methanamine → 2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(4-phenoxybenzyl)-1,1'-biphenyl-4-carboxamide
Reaktionsgleichung
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20](O)=[O:21])=[CH:16][CH:15]=1.[O:23]([C:30]1[CH:37]=[CH:36][C:33]([CH2:34][NH2:35])=[CH:32][CH:31]=1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([CH3:13])=[N:11][N:12]=2)=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([NH:35][CH2:34][C:33]2[CH:36]=[CH:37][C:30]([O:23][C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)=[CH:31][CH:32]=2)=[O:21])=[CH:16][CH:15]=1Komponenten
3
Versuchsvorschrift
2′-Methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(4phenoxybenzyl)-1,1′-biphenyl-4-carboxamide was prepared from 2′-methyl-5′-(5-methyl-1,3,4-oxadiazol-2-yl)-1,1′-biphenyl-4-carboxylic acid and 4-phenoxybenzylamine using method N. NMR; δH [2H6]—DMSO 9.15,(1H, t), 8.00,(2H, d), 7.89,(1H, dd), 7.76,(1H, d), 7.53,(3H, m), 7.37,(4H, m), 7.11,(1H, m), 7.01-6.96,(4H, m), 4.49,(2H, d), 2.56,(3H, s), 2.31,(3H, s). LCMS; retention time 3.76 min, MH+ 476.