2-Aminothiazole → 2-(3,5-Dimethylphenylsulfanyl)nitrobenzene

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2-Aminothiazole	HCID 2155	—
Edukt	1-Fluoro-2-nitrobenzene	HCID 73895	—
Edukt	3,5-Dimethylbenzenethiol	HCID 117548	—
Edukt	2-((3,5-Dimethylphenyl)thio)aniline	HCID 66998967	—
Produkt	N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N'-(thiazol-2-yl)urea	HCID 59733126	74%
Produkt	2-(3,5-Dimethylphenylsulfanyl)nitrobenzene	HCID 66999017	78%

Reaktionsschritte

2-(3,5-Dimethylphenylsulfanyl)nitrobenzene (1.01 g, 78%) was prepared from 3,5-dimethylthiophenol (0.76 g, 5.5 mmol) and 2-fluoronitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(3,5-dimethylphenylsulfanyl)aniline (0.64 g, 72%) following the general procedure B. N-[2-(3,5-Dimethylphenylsulfanyl)phenyl]-N′-(thiazol-2-yl)urea (131 mg, 74%) was prepared from 2-(3,5-dimethylphenylsulfanyl)aniline (115 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07384967B2
Quelldatensatz	uspto-grants-2008_06
ORD ID	ord-e41ede9e832c434b94b3d4104ebcbf1e
Quellennotiz	uspto-grants-2008_06