Ethyl Acetate → {2-[3-(2-Cyclopentanesulfonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester
Reaktionsgleichung
[CH:1]1([S:6]([C:9]2[CH:15]=[C:14]([CH3:16])[CH:13]=[CH:12][C:10]=2[NH2:11])(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:17][C:18]1[S:19][CH:20]=[C:21]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])[N:22]=1.[CH2:29]([O:31]C(=O)C)C>>[CH2:27]([O:26][C:24](=[O:25])[CH2:23][C:21]1[N:22]=[C:18]([NH:17][C:29]([NH:11][C:10]2[CH:12]=[CH:13][C:14]([CH3:16])=[CH:15][C:9]=2[S:6]([CH:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)(=[O:8])=[O:7])=[O:31])[S:19][CH:20]=1)[CH3:28]Komponenten
4
Versuchsvorschrift
{2-[3-(2-Cyclopentanesulfonyl-4-methyl-phenyl)-ureido]-thiazol-4-yl{-acetic acid ethyl ester (305 mg, 68%) was prepared from 2-cyclopentanesulfonyl-4-methyl-aniline (239 mg, 1.0 mmol) and ethyl 2-amino-4-thiazolylacetate (186 mg, 1.0 mmol) following the general procedure D.