HCID 21973129, Verbindung → 1-(2-(5-(4-(methylsulfonyl)phenoxy)-2-(pyridin-2-yl)-1H-benzo[d]imidazol-6-yl)pyrrolidin-1-yl)ethanone
Reaktionsgleichung
[CH3:1][S:2]([C:5]1[CH:31]=[CH:30][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][NH:26]3)=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].CCCCCC.[CH3:38][CH:39]([OH:41])C.C(NCC)C>>[CH3:1][S:2]([C:5]1[CH:6]=[CH:7][C:8]([O:9][C:10]2[C:24]([CH:25]3[CH2:29][CH2:28][CH2:27][N:26]3[C:39](=[O:41])[CH3:38])=[CH:23][C:13]3[NH:14][C:15]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=4)=[N:16][C:12]=3[CH:11]=2)=[CH:30][CH:31]=1)(=[O:3])=[O:4]Komponenten
3
Versuchsvorschrift
230 mg of 5-(4-methanesulfonyl-phenoxy)-2-pyridin-2-yl-6-pyrrolidin-2-yl-1H-benzimidazole obtained in Example 162 (step 7) was optically resolved, using an optical resolution column (CHIRALPAK AD 2 cmφ×25 cmL (by Daicel Chemical), mobile phase: hexane/2-propanol/diethylamine=20/80/0.1, flow rate: 10 ml/min), into an enantiomer A (retention time: 19.0 min) and an enantiomer B (retention time: 32.2 min) each as a yellow oily substance.
Quellen und Nachweise
- ORD-Eintrag
- ord-c4b102d9de8e4ac68969a01a810b2e1e
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer
- US07728025B2
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