2,2,2-Trifluoroethyl trifluoromethanesulfonate → [5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	2,2,2-Trifluoroethyl trifluoromethanesulfonate	HCID 80366	—
Edukt	{5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone	HCID 16754253	—
Edukt	[5-Hydroxy-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 67527268	—
Produkt	[5-[3-(3-Aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1-(2,2,2-trifluoro-ethyl)-1H-indol-2-yl]-morpholin-4-yl-methanone	HCID 16112804	—

Reaktionsschritte

In analogy to the procedure described for the synthesis of intermediate 1, step 1, the title compound was synthesized from {5-[3-(3-aza-bicyclo[3.1.0]hex-3-yl)-propoxy]-1H-indol-2-yl}-morpholin-4-yl-methanone (Example 5, step 4) and 2,2,2-trifluoroethyl-trifluoromethanesulfonate. The title product was obtained in 45% yield as white solid. MS (m/e): 452.5 (MH+, 100%).

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07388095B2
Quelldatensatz	uspto-grants-2008_06
ORD ID	ord-e70956c355d04fa79af0aaa0a047a06f
Quellennotiz	uspto-grants-2008_06