2-Pyrazinecarboxylic acid → 5-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-methanesulfonyl-pyridin-3-oxy)-1H-benzimidazole

HRID 13296

Reaktionsgleichung

Reaktionsgleichung von HRID 13296
[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[CH:6]=[C:7]([NH2:23])[C:8]([NH2:22])=[CH:9][C:10]=1[O:11][C:12]1[CH:13]=[N:14][C:15]([S:18]([CH3:21])(=[O:20])=[O:19])=[CH:16][CH:17]=1.[N:28]1[CH:33]=[CH:32][N:31]=[CH:30][C:29]=1[C:34](O)=O>>[F:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[O:4][C:5]1[C:10]([O:11][C:12]2[CH:13]=[N:14][C:15]([S:18]([CH3:21])(=[O:19])=[O:20])=[CH:16][CH:17]=2)=[CH:9][C:8]2[NH:22][C:34]([C:29]3[CH:30]=[N:31][CH:32]=[CH:33][N:28]=3)=[N:23][C:7]=2[CH:6]=1

Komponenten

3

Edukt 2

HCID 10472-Pyrazinecarboxylic acidHCID 231451984-(2-Fluoro-phenoxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine

Produkt 1

HCID 231456915-(2-Fluoro-phenoxy)-2-pyrazin-2-yl-6-(6-methanesulfonyl-pyridin-3-oxy)-1H-benzimidazole

Versuchsvorschrift

The entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method or by combining it with an ordinary method but using 4-(2-fluoro-phenoxy)-5-(6-methanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 200 and pyrazine-2-carboxylic acid.

Aufarbeitung

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 197 or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-d535770467c64855bd83b71455c91e51
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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