Methanol → Methyl L-ornithine monohydrochloride
Reaktionsgleichung
[ClH:1].[NH2:2][C@H:3]([C:8]([OH:10])=[O:9])[CH2:4][CH2:5][CH2:6][NH2:7].[CH3:11]O>>[ClH:1].[CH3:11][O:9][C:8](=[O:10])[C@H:3]([CH2:4][CH2:5][CH2:6][NH2:7])[NH2:2]Komponenten
3
Versuchsvorschrift
Into a stirred suspension of L-(+)-ornithine hydrochloride (Aldrich) in methanol was bubbled anhydrous hydrochloric acid gas until the solution was saturated. The reaction mixture was capped with a rubber septum and stirring was continued overnight at room temperature. The solvent was then stripped under reduced pressure and the residue triturated with ether. The resulting solid was dried under reduced pressure to afford L-(+)-ornithine methyl ester hydrochloride as a white solid (97% yield).
Aufarbeitung
- customwas bubbled anhydrous hydrochloric acid gas until the solution
- customThe reaction mixture was capped with a rubber septum
- customthe residue triturated with ether
- customThe resulting solid was dried under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-e4574bbd923b462796feb20af5e5002e
- Quelldatensatz
- uspto-grants-2008_06
- Patentnummer
- US07390801B2
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