1-methyl-1H-pyrazole-3-carboxylic acid → 5-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazole

HRID 13322

Reaktionsgleichung

Reaktionsgleichung von HRID 13322
[F:1][CH:2]([F:38])[O:3][C:4]1[C:9]([O:10][C:11]2[C:25]([O:26][C:27]3[CH:28]=[N:29][C:30]([S:33]([CH2:36][CH3:37])(=[O:35])=[O:34])=[CH:31][CH:32]=3)=[CH:24][C:14]3[NH:15][C:16]([C:18]4[CH:23]=[CH:22]C=C[N:19]=4)=[N:17][C:13]=3[CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1.[CH3:39][N:40]1C=CC(C(O)=O)=N1>>[F:1][CH:2]([F:38])[O:3][C:4]1[C:9]([O:10][C:11]2[C:25]([O:26][C:27]3[CH:28]=[N:29][C:30]([S:33]([CH2:36][CH3:37])(=[O:34])=[O:35])=[CH:31][CH:32]=3)=[CH:24][C:14]3[NH:15][C:16]([C:18]4[CH:23]=[CH:22][N:40]([CH3:39])[N:19]=4)=[N:17][C:13]=3[CH:12]=2)=[CH:8][CH:7]=[CH:6][N:5]=1

Komponenten

3

Edukt 2

HCID 5731761-methyl-1H-pyrazole-3-carboxylic acidHCID 114895675-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-pyridin-2-yl-1H-benzimidazole

Produkt 1

HCID 1356979625-(2-Difluoromethoxy-pyridin-3-yloxy)-6-(6-ethanesulfonyl-pyridin-3-yloxy)-2-(1-methyl-1H-pyrazol-3-yl)-1H-benzimidazole

Versuchsvorschrift

The entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method or by combining it with an ordinary method but using 4-(2-difluoromethoxy-pyridin-3-yloxy)-5-(6-ethanesulfonyl-pyridin-3-yloxy)-benzene-1,2-diamine obtained in Example 247 and 1-methyl-1H-pyrazole-3-carboxylic acid.

Aufarbeitung

  1. customThe entitled compound was obtained as a colorless solid in the same method as in Example 203 or in accordance with the method

Quellen und Nachweise

ORD-Eintrag
ord-432da6b11ae548539f0b1457a1ae19c0
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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