2-Pyrazinecarboxylic acid → N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

HRID 13324Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 13324
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([OH:9])=O.Cl.CN(C)CCCN=C=NCC.[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][C:31]=1[F:37])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>N1C=CC=CC=1>[CH2:22]([O:29][C:30]1[CH:36]=[CH:35][C:33]([NH:34][C:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)=[O:9])=[CH:32][C:31]=1[F:37])[C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1

Komponenten

5

Edukt 3

HCID 10472-Pyrazinecarboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 219518923-Fluoro-4-phenylmethoxyaniline

Produkt 1

HCID 23145734N-(4-benzyloxy-3-fluorophenyl)pyrazinecarboxamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2.59 g of pyrazine-2-carboxylic acid and 4.73 g of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide monohydrochloride were added to a pyridine (60 ml) solution of 4.13 g of 4-benzyloxy-3-fluoroaniline, and the reaction liquid was stirred overnight at room temperature. Pyridine was evaporated away under reduced pressure, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a brown solid.

Aufarbeitung

  1. customthe reaction liquid
  2. customPyridine was evaporated away under reduced pressure
  3. additionwater was added to it
  4. filtrationThe resulting deposit was taken out through filtration

Quellen und Nachweise

ORD-Eintrag
ord-4f8f248a00a74e1a95b45c2060380d81
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728025B2

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