Zurück
HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 13326Erstellt: 23. Oktober 2026

Dimethylformamide → N-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamide

https://huagongshe.com/de/reaction/13326

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktDimethylformamideHCID 6228—
Edukt2-FluorophenolHCID 9707—
EduktPotassium CarbonateHCID 11430—
EduktN-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamideHCID 23145743—
LösungsmittelWaterHCID 962—
ProduktN-(4-benzyloxy-5-(2-fluorophenoxy)-2-nitrophenyl)pyrazinecarboxamideHCID 23145658—

Reaktionsbedingungen

Temperatur90 °C

Reaktionsschritte

0.54 ml of 2-fluorophenol and 2.53 g of potassium carbonate were added to a dimethylformamide (16 ml) solution of 2.14 g of N-(4-benzyloxy-5-fluoro-2-nitrophenyl)pyrazinecarboxamide, and the reaction liquid was stirred at 90° C. for 5 hours, and then water was added to it. The resulting deposit was taken out through filtration to obtain the entitled compound as a yellow solid.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07728025B2
Quelldatensatzuspto-grants-2010_06
ORD IDord-76da9412acef46d08b316ba9c7c4c87c
Quellennotizuspto-grants-2010_06