4-Chloroaniline → N-(4-chlorophenyl)alanine Iso-butyl Ester
Reaktionsgleichung
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[C:9]([O:14][CH2:15][CH:16]([CH3:18])[CH3:17])(=[O:13])[C:10]([CH3:12])=O>>[CH2:15]([O:14][C:9](=[O:13])[C@H:10]([CH3:12])[NH:6][C:5]1[CH:7]=[CH:8][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:16]([CH3:18])[CH3:17]Komponenten
3
Versuchsvorschrift
Following General Procedure AA above and using 4-chloroaniline (Aldrich) and isobutyl pyruvate (prepared by following General Procedure AO above), the title compound was prepared as an oil. The reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification was by preparative plate chromatography (silica gel using 25% EtOAc/hexanes as the eluant).
Aufarbeitung
- customThe reaction was monitored by tlc on silica gel (Rf=0.6 in 25% EtOAc/hexanes) and purification
Quellen und Nachweise
- ORD-Eintrag
- ord-440e7439bd1a4e989b679ae7024c4b8a