L-Alanine → N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

HRID 133358

Reaktionsgleichung

Reaktionsgleichung von HRID 133358
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11][C:12]([OH:14])=O.[NH2:15][C@H:16]([C:18]([OH:20])=[O:19])[CH3:17]>>[CH2:1]([O:19][C:18](=[O:20])[C@H:16]([CH3:17])[NH:15][C:12](=[O:14])[CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)[CH:2]([CH3:11])[CH3:3]

Komponenten

3

Edukt 2

HCID 5950L-AlanineHCID 113932-Naphthaleneacetic acid

Produkt 1

HCID 15481768N-[(2-naphthyl)acetyl]-L-alanine Iso-butyl Ester

Versuchsvorschrift

Following General Procedure BB and using 2-naphthylacetic acid (Aldrich) and L-alanine is iso-butyl ester hydrochloride (from Example BB above), the title compound was prepared as a solid having a melting point of 128°-129° C. The reaction was monitored by tlc on silica gel and purification was by extraction with Et2O followed by washes with aqueous K2CO3 and aqueous HCl.

Aufarbeitung

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. extractionwas by extraction with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-b6ffa61a8c7b4a9cb5f26d2206c05357
Quelldatensatz
uspto-grants-2008_06
Patentnummer
US07390801B2

Verknüpfte Notizen

Wird geladen…